遺伝子治療の新規技術開発を目指した非ウイルスベクターを用いたデリバリー技術の専門性を有する研究員 / Research Scientist - Non-Viral Vector Delivery Technologies for Novel Gene Therapy Development

3つの主要な創薬モダリティにおいて、技術を積極的に強化してきました。私たちは、独自の技術力を駆使して、従来のモダリティでは解決が困難だった医療ニーズに応える新たな治療方法の開発を目指しています。これは、中外製薬特有の高付加価値を生み出す技術ドリブン型の創薬アプローチによるものです。

LNPなどの非ウイルスベクターの開発によって、体内の特定の細胞に対して選択的かつ効率的に遺伝子を導入する独自の技術を開発し、遺伝子デリバリー創薬分野における競争力を確立します。さらに、開発した技術を活用した新たな治療法の探索を行い、従来の技術ではアプローチが困難だったターゲットや疾患領域での創薬プロジェクトの提案および推進を担当していただきます。様々な専門性を有する研究員と協働しつつ、ご自身の専門性を発揮していただくことで、革新的な成果を創出します。

Background to recruitment :

At Chugai Pharmaceutical, we aim to continuously develop and deliver innovative drugs. To this end, we have actively strengthened our technologies in the three major drug discovery modalities : antibodies, small molecules, and mid-size molecules. Leveraging our proprietary technological capabilities, we are striving to develop new therapeutic approaches that address unmet medical needs which have been difficult to solve with conventional modalities. This is driven by our technology-driven drug discovery approach, which generates high added value unique to Chugai Pharmaceutical.

Currently, we are promoting the development of gene delivery technologies as a new drug modality. This technology enables future therapies by precisely delivering genes to specific cells in the body and allowing them to function specifically. While building upon the drug discovery technologies cultivated by Chugai Pharmaceutical, we are collaborating with cutting-edge external partners from around the world to develop innovative therapies unique to Chugai Pharmaceutical. To establish our proprietary technology platform in this field and realize the development of groundbreaking medicines that can change the lives of patients worldwide, we are recruiting talented individuals to become new leaders.

Description of work :

Candidates are expected to develop proprietary technologies utilizing non-viral vectors such as LNPs that enable selective and efficient gene delivery to specific cells within the body. This will help establish Chugai's competitiveness in the gene delivery drug discovery field. Additionally, candidates are encouraged to explore novel gene therapies by leveraging these developed technologies, proposing and driving projects targeting areas and diseases that have been difficult to approach through conventional methods. Collaborating with researchers from various specialties, you will apply your expertise to generate innovative results. 応募資格／Qualifications 求める経験

DDSの研究（1つ以上、かつ3 ~ 10年以上の経験を有する方）

LNP等の新規非ウイルスベクターの開発・分析に関する研究

LNP等の新規非ウイルスベクターを応用した創薬研究

3 ~ 10年以上の経験を有する方）

Desired experience :

Candidates are expected to have experience in one or more of the following research areas related to non-viral vector-mediated gene delivery / nucleic acid drug delivery systems for 3 ~ 10 years or more :

Research on the development and analysis of novel non-viral vectors such as LNPs

Drug discovery research applying novel non-viral vectors like LNPs

Cutting-edge research in the field of gene delivery technologies

Additionally, candidates should have experiences for 3 ~ 10 years or more in :

Taking the lead in proposing and driving research projects

Presenting their research findings through publications and at conferences

Experience in new technology development and patent application in this research field will be considered plus.

1つ以上）

LNP, liposome, EV, VLP, etc.)への核酸封入体の調製・分析

conjugate体の調製・分析

Desired skills / knowledge / abilities :

Ability to propose attractive new ideas and persistently produce results

Experience and knowledge in one or more of the following research skills :

Preparation and analysis of nucleic acid formulations for encapsulation into non-viral vectors (LNPs, liposomes, EVs, VLPs, etc.)

Skills in surface modification of non-viral vectors, such as the preparation and analysis of conjugates with antibodies or other moieties

Evaluation of the intracellular dynamics of vector components and encapsulated nucleic acids

Desired competencies :

Able to accurately understand needs through communication with stakeholders, think through the ideal state, and set goals independently

Even in difficult situations, can identify the most critical issues, strategically tackle them, and persistently pursue results

Can exercise leadership in driving work forward while gaining cooperation from surrounding team members, and build good relationships

5年以上、博士卒の場合は3年以上の実務経験を有する（実務経験の場はアカデミア / 企業を問わない）

3報以上あることが望ましい

TOEIC 730点以上）

Desired Qualifications :

A master's degree or higher in a life science research field such as medicine, pharmaceuticals, engineering, or biology. A doctoral degree is preferable.

For those with a master's degree, at least 5 years of practical experience is required. For those with a doctoral degree, at least 3 years of practical experience is required. Experience can be from academia or industry.

For those from academia, it is desirable to have at least 3 publications as the first author.

Proficient English skills required (TOEIC score : 730 or above)

Position Features：

At Chugai Pharmaceutical, we are recruiting talented individuals who can contribute to the development of innovative pharmaceuticals by leveraging our proprietary drug discovery platform. Our mission is to provide new hope to patients who lack adequate treatment options. To achieve this goal, we will provide you with opportunities to work alongside world-class scientists and fully utilize and expand your expertise. Based on your specialized knowledge, we aim to explore uncharted research areas and develop pharmaceuticals that can deliver substantial value to patients and society worldwide. We wholeheartedly welcome those who wish to take on this valuable challenge and contribute their expertise alongside us.ｖ 待遇／Salary & Benefits 当社規定により優遇いたします

To be decided in accordance with our criteria

The notification of working conditions will be made in an electronic file.

If you apply, please understand this point.