Exploratory ADME Scientist, Oncology Research

Description

Purpose & Scope】

Formulation & ADME drives the optimization of drug candidates through globally competitive formulation development and advanced ADME / safety strategies from the early stages of oncology drug discovery to clinic. This role supports to provide the strategic guidance on the optimization of drug candidates' ADME / safety / physicochemical properties, accelerates the DMTA cycle through strategic study plan and the delivery of high-quality, high-quantity, and high-speed readouts, and establishes ourselves as a formulation and ADME group with global competitiveness. We are looking for individuals who can add values to Oncology Research!

Essential Job Responsibilities】

Act as an outstanding scientist of discovery ADME function.

Responsible for the analysis, interpretation, integration and reporting of preclinical ADME data.

As part of the integrated project teams, design and execute in vitro / in vivo studies to understand the relationship between pharmacokinetics (PK) and pharmacodynamics (PD).

Clarify ADME profiles to optimize compounds based on their ADME profiles requirements, ensuring alignment with project timelines and regulatory standards.

Interact / manage external vendors (CROs, academic sites etc.) for conducting in vivo and in vitro experiments.

Align with overall Oncology Research strategy and objectives.

Partner with other teams in Oncology Research as well as Development to translate scientific insights into actionable ADME / formulation strategies.

Qualifications】

Must＞

Science degree MS, or exceptional experience in Pharmaceutical Sciences, Chemistry, Biochemistry, Pharmacology, or a related field.

At least 7 years relevant experience in pharmaceutical company or in academic research with a good understanding of Drug Discovery and Development.

Knowledge for drug formulation, ADME, safety or drug delivery is desirable.

Skills in LBA and / or LCMSMS analysis for engineered small molecules, peptides, ADCs, multifunctional antibodies.

Experience with laboratory techniques and animal handling.

Communication skills (active & passive) in own language and in English.

Want＞

Demonstrated expertise in developing and implementing ADME screening methods and establishing SARs for small molecule, antibody, and ADC.

Experience in drug development and familiarity with cancer therapeutics.