Bioconjugation Lead

Description 【募集の背景 / Purpose & Scope】 This pivotal role involves providing strategic, scientific, and operational leadership for our antibody drug conjugate (ADC) research, primarily focusing on bioconjugation strategies and their interplay with antibody characteristics. The position holder will drive the design and development of novel ADC candidates and support the Research Lead (Res-L) from a scientific and resource management perspective to accelerate projects. This position reports directly to the Head of Antibody Drug Conjugate. 【職務の内容 / Essential Job Responsibilities】 （雇入れ直後） Scientific & Technical Leadership : -Provide scientific vision, strategic direction, and technical oversight for the Bioconjugation team, ensuring the delivery of well-characterized ADC candidates.-Collaborate closely with the Antibody Engineering team to define optimal antibody characteristics for conjugation and contribute to the antibody selection strategy for ADC projects-Lead the design, development, optimization, and execution of novel and established bioconjugation methodologies for creating ADCs, including site-specific conjugation techniques.-Stay at the forefront of bioconjugation technologies, ADC development, and relevant analytical advancements; evaluate and implement new technologies and approaches to enhance team capabilities and productivity.-Troubleshoot and resolve complex scientific and technical challenges related to bioconjugation, purification, and characterizationTeam Management & Development : -Lead, manage, mentor, and develop a team, fostering a culture of scientific excellence, innovation, collaboration, urgency, and accountability.-Ensure appropriate resource allocation, project planning, and timeline management for the Bioconjugation team.Project & Stakeholder Management : -Drive bioconjugation aspects of ADC projects from early discovery to development candidate selection, ensuring timely delivery of high-quality data and materials.-Collaborate effectively with cross-functional teams, including antibody engineering, medicinal chemistry (payload and linker synthesis), analytical development, DMPK, pharmacology, CMC, and external partners.-Contribute to the preparation of technical reports, patent applications, and regulatory submission documents. （変更の範囲） 会社内での全ての業務【応募要件 / Qualifications】 ＜必須 / Must＞ -Ph.D. in Chemistry, Biochemistry, Bioengineering, or a closely related field. -Minimum of 10 years of experience in the biopharmaceutical industry, with a significant portion focused on Antibody Drug Conjugate development. -Proven track record of scientific accomplishment and leadership in the biologics field, evidenced by publications, patents, and successful advancement of therapeutic candidates. -Significant hands-on experience and deep understanding of protein chemistry, bioconjugation techniques, and purification methods for proteins and ADCs. -Experience in identifying, evaluating, and developing novel technologies. -Proven ability to think strategically and contribute to R&D portfolio planning. -Excellent communication, interpersonal, and presentation skills, with the ability to effectively communicate complex science to diverse audiences. -Demonstrated ability to work collaboratively in a cross-functional, matrixed environment. -Minimum of 3 years of experience in leading and managing scientific teams. ＜歓迎 / Want＞ -Experience in the development or application of site-specific conjugation technologies -Knowledge and experience in stability assessment of ADCs, pharmacokinetic (DMPK) characterization, and in vitro / in vivo efficacy evaluation. -Experience in the implementation and utilization of high-throughput bioconjugation methods and automation technologies. -Knowledge or experience in CMC development of ADCs.